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M9480580.TXT
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1994-08-20
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Document 0580
DOCN M9480580
TI The in vivo expression of cytokine genes in humans.
DT 9410
AU Galanaud P; Unite d'Immunopathologie et Immunologie Virale de l'INSERM;
(Unite 131), l'Association Claude Bernard, Universite de; Paris-Sud,
Hopital Antoine Beclere, Clamart, France.
SO J Lipid Mediat Cell Signal. 1994 Feb;9(1):37-41. Unique Identifier :
AIDSLINE MED/94305939
AB We used in situ hybridization to study the expression of interleukin
genes in sarcoidosis and in persistent generalized lymphadenopathy of
HIV disease. In both cases, we found a dramatic over-expression of the
interferon-gamma (IFN-gamma) gene as compared to that of the
interleukin-2 (IL-2) gene. In sarcoidosis, IFN-gamma producing cells are
CD4 T cells and are associated with IL-1 beta gene expressing monocytic
cells. In HIV lympadenopathy IFN-gamma producing cells are C8 T cells
engaged in cytotoxic function, as demonstrated by the concomitant
expression of serine esterase B gene. Thus distinct patterns of
interleukin production can be defined in vivo in selected
immunopathological situations.
DE Biopsy Comparative Study *Gene Expression Human HIV
Seropositivity/*IMMUNOLOGY/METABOLISM/PATHOLOGY Interferon Type
II/*BIOSYNTHESIS/GENETICS Interleukin-1/BIOSYNTHESIS/GENETICS
Interleukin-2/BIOSYNTHESIS/GENETICS Interleukin-6/BIOSYNTHESIS/GENETICS
Interleukins/*BIOSYNTHESIS/GENETICS Lymph
Nodes/IMMUNOLOGY/*METABOLISM/PATHOLOGY Reference Values
Sarcoidosis/*IMMUNOLOGY/METABOLISM/PATHOLOGY JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).